Polyazaacenes: new tricks for old dogs*

Teaching Old Dogs New Tricks Implementing Organizational Learning in an Asian National Police Force

Can old dogs learn new tricks?

Many of these old adages can’t be traced back to their origins, but the reference to senior dogs and their learning capacity has a documented origin. The source of these well-worn words is an English gentleman named Fitzherbert who wrote a treatise on animal husbandry in 1523. In the cumbersome vernacular of the times, he said that “the dogge must lerne when he is a whelpe, or els it wyl not be...

Resistance: what is new and on the horizon, and a time to teach old dogs new tricks?

Understanding HIV drug resistance has played a key role in the success of antiretroviral therapy. This knowledge allowed for the prediction of resistance evolution when a specific drug or combinations of drugs were administered, informing strategies implemented for initial and subsequent drug regimens. Resistance testing of individual patients detects transmitted as well as acquired drug resist...

Fosfomycin for Treatment of Prostatitis: New Tricks for Old Dogs.

Treatment options for prostatitis caused by multidrug-resistant gram-negative bacilli are limited. We report two cases cured with oral fosfomycin and provide a pharmacokinetic analysis of fosfomycin predose concentrations during treatment.

Have you seen? tRNAs: new tricks from old dogs

tRNA biology has lately seen a revival with the discovery of tRNA cleavage products as mediators of stress responses. In this issue of The EMBO Journal, Blanco et al now report that tRNA methylation, by protecting from cleavage, is relevant for normal brain development. The versatility of tRNA is further emphasized by a recent study in Cell that uncovered differential expression of tRNAs as a m...